DNA replication

Identify the underlying mechanism associated with the initiation of focal amplification in breast cancer

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In breast cancer, focal amplification of oncogenes plays a critical role in oncogenesis. A recent study published in Nature used whole genome sequencing (WGS), RNA sequencing and epigenomic data to identify the underlying mechanism associated with the initiation of focal amplification in breast cancer. Study: ERα-associated translocations underlie oncogene amplifications in breast cancer. Image Credit: … Read more

Researchers take inspiration from viruses to make glioblastoma more vulnerable to treatment

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In the tough war against glioblastoma, scientists are drawing inspiration from viruses to make aggressive cancer more vulnerable to treatment. Their target is SAMHD1, a protein that can protect us from viral infections by destroying an essential DNA building block that viruses and cancer need to replicate. But they found that SAMHD1 also has the … Read more