Researchers from the Quadram Institute and the University of East Anglia have identified what makes certain strains of gut bacteria potentially deadly in premature babies. The results will help identify and track dangerous strains and protect vulnerable newborns. Necrotizing enterocolitis (NEC) is a major threat to extremely low birth weight newborns. Rare in full-term babies, … Read more
Written in the May 22, 2023 issue of Cellular systems, a diverse team of scientists, led by researchers at the University of California San Diego School of Medicine, has produced a new map that describes the human body’s extremely complicated and highly evolved system for treating and repairing damage to DNA; a cause and consequence … Read more
In a recent study published in the Open JAMA Networkresearchers performed a genetic association study using a Mendelian randomization (MR) framework to assess associations between genetically determined modifiable risk factors, such as high-density lipoprotein (HDL) cholesterol, systolic blood pressure (SBP) and Alzheimer’s disease (AD). They worked with a large genomic dataset, the European Alzheimer’s Disease … Read more
In breast cancer, focal amplification of oncogenes plays a critical role in oncogenesis. A recent study published in Nature used whole genome sequencing (WGS), RNA sequencing and epigenomic data to identify the underlying mechanism associated with the initiation of focal amplification in breast cancer. Study: ERα-associated translocations underlie oncogene amplifications in breast cancer. Image Credit: … Read more
Mount Sinai researchers have cataloged thousands of sites in the brain where RNA is modified throughout human life in a process known as adenosine-inosine (A-to-I) editing, offering important new avenues for understanding the cellular and molecular mechanisms of brain development and their impact on health and disease. In a study published in Cell reportsthe team … Read more
In a recent study published on bioRxiv* preprint server, researchers investigated whether low complexity regions (LCRs) were more responsible for the current clade IIb 2022 monkeypox virus (MPXV) outbreak rather than single nucleotide polymorphisms (SNPs) . Study: Changes in a new type of genomic accordion may open the palette to increased transmissibility of monkeypox. Image … Read more
In a recent study published on bioRxiv* preprint server, researchers in the United States have explored a new technique to improve representation in viral genomic surveillance. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) escaped detection in the early stages of transmission due to the lack of regular viral genomic surveillance, allowing the virus to proliferate … Read more