2023 PCRF grant recipients announced for exploring new, safer treatments for childhood cancers

The Pediatric Cancer Research Foundation (PCRF), a nonprofit organization focused on transforming pediatric cancer care by accelerating research breakthroughs, today announced the 19 recipients of its 2023 research grants. will receive $1,730,000 in funding to explore new, safer treatments for childhood cancers. Among the beneficiaries, six scientists are receiving funding from the PCRF for the … Read more

Defective proteins involved in ER phagy may cause neurodegenerative diseases

Our cells are traversed by a system of tubes and membrane pockets called the endoplasmic reticulum (ER). It is crucial for the production of biomolecules and is continuously built up and degraded. The degradation, known as ER-phagy, is promoted by the protein ubiquitin, which controls many processes in the cell. If proteins involved in ER … Read more

Death of 43-year-old marks entry of ‘zombie’ drugs into UK

The death of a 43-year-old man is the first in the UK to be linked to xylazine and marks the drug’s entry into the UK drug supply. New research published in the Journal of Forensic and Forensic Medicine from King’s College London details the man’s death in May 2022 from the effects of xylazine alongside … Read more

Hydrogen sulfide can be used to support photothermal cancer therapy

Hydrogen sulfide is generally a highly toxic gas. However, with careful preparation, it can be used to support photothermal therapy (PTT) in the treatment of cancer, according to a team of researchers reporting in the journal applied chemistry recently discovered. As the team reports, a hydrogen sulfide-releasing adjuvant causes tumor cells to lose their natural … Read more

The potential clinical benefit of the Multabody platform as a therapeutic for SARS-CoV-2

In a recent article published in the Science Translational Medicine Journal, researchers demonstrated that the combination of avidity and specificity of traditional monoclonal antibodies (MAbs) could extend their neutralization reach and resilience against viral diversity using a multispecific, multiaffinity antibody platform (Multabody, MB) derived from human apoferritin protomer. Study: A multi-specific, multi-affinity antibody platform neutralizes … Read more

An important step towards defining long COVID

A study led by the National Institutes of Health’s RECOVER Initiative and supported by NYU Langone Health, which houses the Clinical Science Core (CSC) of the effort, provides an expanded working definition of long COVID. This study is an important step towards defining long COVID beyond any individual symptom. This definition – which may … Read more

Screening delays during the COVID-19 pandemic are likely to increase cancer cases

According to a new research article published in the Journal of the American College of Surgeons (JACS). While the medical system as a whole has taken an incredible burden from the COVID-19 pandemic, we are now going to see a much different burden present itself due to delays in cancer detection. With this study, … Read more

New vaccine offers hope of beating epidemic meningitis by 2030

A trial of a new vaccine against meningococcal disease, a cause of meningitis and blood poisoning, has been found to be safe and induces a strong immune response against five strains of meningococcal bacteria: A, C, W, Y and X. The phase 3 trial compared the immune response generated by the new pentavalent vaccine NmCV-5 … Read more

Study sheds light on global disparities in liver disease death rates

New research sheds light on global disparities in death rates from advanced liver disease, also known as cirrhosis. The study, published Monday in Lancet Gastroenterology and hepatologyfound that the risk of death for hospitalized patients with cirrhosis was more than twice as high in low- and lower-middle-income countries compared to high-income countries, mainly due to … Read more

People with Alzheimer’s disease are more likely to develop epilepsy and vice versa

People with a genetic predisposition to Alzheimer’s disease may have an increased risk of epilepsy, and people with a certain type of epilepsy may have an increased risk of developing Alzheimer’s disease, according to a study published in the May 24, 2023 online issue of Neurology®the medical journal of the American Academy of Neurology. … Read more